Cardiac Medicine Certification (CMC) Practice Exam

What is the role of thiamine in relation to diuretic therapy?

1. It is contraindicated

2. It is depleted and needs monitoring

3. It enhances diuresis

4. It helps to regulate blood pressure

The correct answer is: It is depleted and needs monitoring

Thiamine, also known as vitamin B1, is crucial for carbohydrate metabolism and energy production within the body. When patients are on diuretic therapy, particularly those taking loop diuretics or thiazide diuretics, there is a risk of thiamine depletion. This happens because diuretics increase urine output, which can lead to the excretion of not only water and electrolytes but also vitamins and nutrients, including thiamine. Monitoring thiamine levels in patients on long-term diuretic therapy is important, especially in populations at risk for thiamine deficiency, such as those with chronic conditions, poor nutritional intake, or alcoholism. Adequate thiamine levels are essential since deficiency can lead to various complications, including Wernicke's encephalopathy. Understanding thiamine's role in relation to diuretic therapy emphasizes the need for nutritional monitoring in patients receiving these medications to prevent deficiencies that could affect overall health and recovery.